Characterization of a Myocardial Depressant Factor Isolated from Cardiogenic Shock

A circulating myocardial depressant substance in septic shock.

Recovery from cardiogenic shock complicating right ventricular myocardial infarction.

Introduction Recently the din ical and haemodynamic complica tions of predominant right ventricular infarction have become clear1, 1 . ~ . S_ Although the condition is uncommon it'i importance li~s in the high incidence of cardiogenic shock which in sharp contrast to shock complicating left ventricular infarction, ca rries a good prognosis . A 60 per cen t surviva l has been reported from a sop...

A Circulating Myocardial Depressant Substance in Humans with Septic Shock

We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclidedetermined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocardial cells. The contraction of a singl...

Cardiogenic shock complicating acute myocardial infarction.

Although numerous clinical complications are associated with the development of acute myocardial infarction (AMI), none are more potentially devastating or carry a worse prognosis than cardiogenic shock (CS). It’s the leading cause of death in patient hospitalized with AMI and continues to complicate between 5-8% of ST-elevation myocardial infarction (STEMI) and approximately 2.5% of non-ST-ele...

Cardiogenic shock in acute myocardial infarction.

D espite the marked reduction in mortality from acute myocardial infarction (AMI), which may be as low as 3% to 4% with today’s national guidelines for rapid, catheter-based revascularization to open the infarct-related artery, cardiogenic shock remains the leading cause of death from AMI, occurring in as many as 10% of all myocardial infarctions (1). Unfortunately, the outcome with current tre...